张虹博士生等著的论文Mechanisms of the Acute Ischaemia-induced Arrhythmogenesis- A Simulation Study在SCI杂志Mathematical Biosciences发表。该杂志在2006年第203卷的第1期（Pages 1-18），在首篇位置发表了长达18页的该文。
到目前为止，张虹博士生发表的论文已经被SCI杂志收录4篇。
论文的摘要如下：
Abstract
The underlying ionic mechanisms of ischemic-induced arrhythmia were studied by the computer simulation method. To approximate the real situation, ischemic cells were
simulated by considering the three major component conditions of acute ischemia (elevated extracellular K+ concentration, acidosis and anoxia) at the level of ionic currents and ionic concentrations, and a round ischemic zone was introduced into a homogeneous healthy sheet to avoid sharp angle of the ischemic tissue. The constructed models were solved using the operator splitting and adaptive time step methods, and the perturbation finite difference (PFD) scheme was first used to integrate the partial differential equations (PDEs) in the model. The numerical experiments showed that the action potential
durations (APDs) of ischemic cells did not exhibited rate adaptation characteristic, resulting in flattening of the APD restitution curve. With reduction of sodium channel
availability and long recovery of excitability, refractory period of the ischemic tissue was significantly prolonged, and could no longer be considered as same as APD.
Slope of the conduction velocity (CV) restitution curve increased both in normal and ischemic region when pacing cycle length (PCL) was short, and refractory period dispersion increased with shortening of PCL as well. Therefore, dynamic changes of CV and dispersion of refractory period rather than APD were suggested to be the fundamental mechanisms of arrhythmia in regional ischemic myocardium.
Keywords: Computer simulations; Myocardial ischemia; Reentry; Ventricular arrhythmias
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