我所吴红博士的一篇论文发表并被SCI收录
杂志2003年影响因子：0.915
Title: Preparation of sodium fluoride-loaded gelatin microspheres, characterization and cariostatic studies
Author(s): Wu H, Zhang ZX, Zhao HP, Wu DC, Wu BL, Cong R
Source: JOURNAL OF MICROENCAPSULATION 21 (8): 889-903 DEC 2004
Document Type: Article
Language: English
Cited References: 41 Times Cited: 0
Abstract: Sodium fluoride-loaded gelatin microspheres (NaF-GMS) were prepared using double-phase emulsified condensation polymerization. The average diameter of microspheres was (11.33 +/- 5.56) mum. The drug content and encapsulation efficiency were 8.80% and 76.73%, respectively. The fluoride releasing profiles of NaF-GMS in physiological saline and artificial saliva (pH 4.5, pH 6.8) showed that NaF-GMS had a sustained-release property and fluoride release rate was increased in pH 4.5 artificial saliva. Experiments conducted in rabbits' oral cavity using NaF-GMS and NaF solution as control revealed NaF-GMS could maintain oral fluoride retention longer than NaF solution. Cariostatic abilities of NaF-GMS including demineralization prohibition in vitro. fluoride deposition in artificial dental plaque and the ability of targeting to cariogenic bacteria were investigated in artificial dental plaque. The results indicated NaF-GMS with lower fluoride concentrations could achieve equivalent cariostatic effect to the concentrated NaF solution, at the same time. Could prolong fluoride retention in dental plaque. Microscopic observation showed that NaF-GMS carrying fusion protein of glucan-binding domain could adhere, more bacteria than NaF-GMS and this might indicate the possibility of targeting to cariogenic bacteria when NaF-GMS were properly modified.
Author Keywords: sodium fluoride; gelatin microspheres; dental caries; dental plaque; sustained-release; demineralization
KeyWords Plus: IN-SITU; STREPTOCOCCUS-MUTANS; RELEASE TABLETS; BIOADHESIVE; ENAMEL; CARIES; RETENTION; SYSTEM; NASAL; ACID
Addresses: Zhang ZX (reprint author), Xian Jiaotong Univ, Sch Life Sci & Technol, Key Lab Biomed Informat Engn, Minist Educ, Xian, 710049 Peoples R China
Xian Jiaotong Univ, Sch Life Sci & Technol, Key Lab Biomed Informat Engn, Minist Educ, Xian, 710049 Peoples R China
Fourth Mil Med Univ, Coll Stomatol, Dept Operat Dent & Endodont, Xian, 710032 Peoples R China
Fourth Mil Med Univ, Fac Preclin Med, Dept Chem, Xian, 710032 Peoples R China
E-mail Addresses: zxzhang@mail.xjtu.edu.cn
Publisher: TAYLOR & FRANCIS LTD, 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
Subject Category: CHEMISTRY, APPLIED; ENGINEERING, CHEMICAL; PHARMACOLOGY & PHARMACY
IDS Number: 886DB
ISSN: 0265-2048